Definium's LSD-based depression pill delivers strong late-stage results

23 points by bushwart 2 days ago|12 comments

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vortep 2 days ago

How do you do a double-blind with a drug that perceptibly changes your state of mind?

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RugnirViking 2 days ago

I guess you do it anyway? the change in the state of mind is thought to be at least in part the mechanism of action, no? so if thats what makes it work, its good to test it against a non hallucinogen

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fragmede 2 days ago

You can't, and it's a real problem for some people. Other people realize that, like testing the efficacy of parachutes by throwing two people off an airplane, one without a parachute; other people realize the double blind standard can't be applied but that the results aren't woo mystical astrology unfounded conclusions despite that.

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thepotatodude 23 hours ago

academia is struggling to realize this

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amanaplanacanal 2 days ago

What is their dosing schedule? It says single dose, but how much are they giving?

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tclover 2 days ago

It’s a single 100-microgram dose. It temporarily dampens the Default Mode Network (DMN), creating a "reset window" for the brain to rebuild its pathways. https://ir.definiumtx.com/news-events/press-releases/detail/...

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andsoitis 2 days ago

pretty exciting if this passes FDA approval. it's getting close.

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Acrobatic_Road 2 days ago

I'm going to skip the line on this one.

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znpy 2 days ago

> Definium Therapeutics tab said a single dose of its LSD-based experimental pill significantly reduced symptoms of major depression

Reminds me of Soma from “brave new world” by aldus huxley.

We’re only missing a way to generate some pre-conditioned humans and we’re pretty much done (birthrates are already falling anyway, no need for malthusian practices).

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evanjrowley 19 hours ago

Aldus Huxley was a proponent of LSD[0]. The Soma in his Brave New World is not meant to represent it.

[0] https://daily.jstor.org/when-aldous-huxley-dropped-acid/

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fragmede 2 days ago

Do other antidepressants, of which there are many, remind you of Soma as well?

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qsxfthnkp2322 2 days ago

What happens if I take 10?

Oh wait. That layoff caused my health insurance to quit working.

Oh well, can’t have any fun these days.