I have other retina permanently damaged, and suffer from double vision when looking small objects like text.
Cancer is a sensible answer.
It looks like one of the optimization edges walked by evolution is a conflict between longevity and the ability to repair and regenerate versus not getting cancer.
It’s easy to make human cell lines immortal, but that will kill you.
One route I can imagine to radical life extension is to start by editing the genome to introduce much more robust but different anti cancer adaptations. Then start turning regenerative stuff and things like telomerase back on.
It's visible in death causes - pretty much all non accident deaths are divided between cancer and heart attack.
A very interesting thing discussed in that podcast was about transgenic (or maybe all?) lab mice bred in USA. These mice are used for initial screening for nearly all drugs. And due to some error and ignorance, unbeknownst to most people using the mice, nearly all mice are predominantly on one side. (Sorry, don't remember which). They just all come from the same family.
Which means that nearly all drugs in the past few decades are skewed toward either giving people cancer or heart attacks.
This is due to mice being extra resistant to one of these and therefore not properly signaling when the drug is likely to give people heart attacks or cancer.
Sorry, don't remember which it is exactly.
This short video talks about telomere-snipping transcription factors that make seemingly-dead cells revert to normal or even to stem cells, but the factors only act when under artificially-maintained conditions:
Until today, it recovered completely
Besides the blood getting everywhere and needing superglue to stop it, it grew back completely fine.
Additionally, too low angle will make the knife very suspectible to blunting and/or require constant drawing on the sharpening steel¹. Unless you have super high quality steel like Japaneese knifes or some craft smith knifes.
Butcher knifes, to be used along with a chainmail glove, are fine. Just don't test their sharpness on body parts. Or use them to shave a bit of hair, but very carefully.
1: https://www.dick.de/messer/en/sharpening/dickoron-family/dic...
There is a sentence among cooks: "only with a stub/butt knife you cut yourself" - isnt this true anymore?
BUT!, once the knife is sharp enough for a job, and I mean for comfortable work, not just barely enough, then it's enough.
Giving somebody who never held a sharp knife in their life a knife that is so sharp it will cut their fingers without them feeling it (or even close to that sharp) is like telling somebody to run a coding agent on their system and not in a VM. Things can get bad really fast.
Most people (at least in central Poland where I come from) used semi blunt knives* for everything. Some would have a household knife sharpener or maybe even low quality sharpening steel like the ones you get in a knives set. Maybe they or their grandma had a butcher in the family. They will have nice sharp knives that can cut tomatoes without crushing them.
But with a knife that is sufficiently thin, a throwaway leather belt, a little skill and an hour or more of time, you can get a mirror-like polished blade that is so sharp you can amputate limbs in seconds. Just need to go through the joint at a correct angle.
That's how our grandfathers shaved.
* just realized I was typing plural for knives wrong - with an 'f'
Is this sentence better?
“Until today” is one of those English phrases that is particularly unfair on non-native speakers. You know “until” and you know “today” and so it’s completely natural to combine them in the way you did.
But as ever, English is dumb and annoying and hard work, all at the same time.
https://as.tufts.edu/biology/tufts-center-regenerative-and-d...
In a frog they were able to grow legit eyes in the gut just by artificialy inducing a certain voltage in that area. No need for any cell transplantations: the voltage really seems to be the only signal needed.
This might also be how it might be done in the future in humans: block scar tissue then induce voltage with the signature of the organ you wish to regrow.
(Probably for a good reason)
Like the way slime molds solve mazes: explore every possible path in parallel, and push growth in all areas with greater nutrient gradients. Not by sensing any gestalt clues, like symmetries in the maze design.
Astoundingly stupidly smart.
Found it: http://news.bbc.co.uk/2/hi/7354458.stm
Dude's brother had him throw his product on the finger as it did so, definitely an astute marketing trick. https://www.theguardian.com/science/2008/may/01/finger.claim
To be fair, the person being skeptical is just a surgeon, this is not a peer-reviewed study or anything actually scientific.
Your NPR link even shows that scientists realize there are still unknowns:
> "We think that nail stem cells may a have a special function to induce the whole regeneration process, including nerve attraction and growth of the bone," Ito say.
A cursory search seems to say that typical regrowth of a nail takes 4-6 months, but Spievak claimed his only took 4 weeks.
Can we say definitively that his "pixie dust" had nothing to do with it? I don't think so. Can we say it did have something to do with it? Also unknown... but the answer right now IMO certainly isn't a scientific "no."
For His own mysterious reasons, He simply doesn’t go in for that stuff, however much intercessionary prayer ends up in His inbox.
I think this is what all healers used. They were all way ahead of their time and clearly misunderstood.
in Folio 43a of Tractate Sanhedrin of the Babylonian Talmud as follows:
‘It is taught: On the eve of Passover they hung Yeshu and the crier went forth for forty days beforehand declaring that "[Yeshu] is going to be stoned for practicing witchcraft, for enticing and leading Israel astray.”’
The relevant portions of the Bible record that the Jews of the Sanhedrin acknowledged the signs and miracles but said it was by the power of Satan that he did these things.
What’s your evidence for this claim?
Vespasian apparently healed blind people in Alexandria. Apollonius of Tyana had a very colourful life performing all kinds of magic. Honi the Circle Maker was bringing the rain over in Judea.
Must've been something in the water other than lead!
a 4 word summary of the entire works of every religion in the world, ever -- the original Pascal's Wager flavored FOMO social networking maneuver.
Signed, 50 years an atheist.